Myxovirus Resistance Protein A (MxA)
Quantitative whole blood test
The Alarm for Viral Infections
Myxovirus Resistance Protein A(MxA)
Quantitative whole blood test The Alarm for Viral Infections
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Rapid
Results available in 8 minutes. With a half-life of 2.3 days, it offers a wide detection window.
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Convience
Whole blood sample applicable.
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Screening tool
A broad-spectrum antiviral agent, expressed against both upper and lower respiratory tract viral infections.
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High Specificity
MxA is not expressed in non-viral infections.
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High Sensitivity
Rapidly elevates within 1-2 hours upon interferon stimulation induced by viral infection, peaking at 16 hours. Its sensitivity is higher than that of antigen-based detection products.
Mechanism
Alarm Signal
Type I interferon / Type III interferon
Antenna
Activate the receptors IFNAR1/IFNAR2 or IFNLR1/IL10R2 on the cell membrane
Switch
Activate the tyrosine kinases JAK1 and TYK2
Signal Transporter
Catalyze the phosphorylation (P) of STAT1 and STAT2 to form the
trimeric complex ISGF3
Commander
Relocate to the nucleus, recognize and bind to the promoter region of
interferon0stmulated response elements (ISREs), activate transcription,
and initiate the expression of interferon-stimulated genes(ISGs)
Antiviral Warrior
Increase the yields of a series of antiviral gene products to inhibit viral
replication and transmission. Example: MX1, MX2, OAS, PKR, etc.
Wang, Y. et al. Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature 465,483-486 (2010)。
Zav' yalov,v.p., Hämäläinen-Laanaya,H.,Korpela, T.k. & Wahlroos,T.Interferon-Inducible Myxovirus Resistance Proteins: Potential Biomarkers for Differentiating Viral from Bacterial Infections. Clin.
Chem.65,739-750 (2019)。